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Lithium Levels: Therapeutic Range

Published by Arlen "Buddy" Castenada on July 17, 2024
The therapeutic range and recommended frequency of lithium blood level monitoring for individuals with bipolar disorder are as follows:

Therapeutic Range:

  • Acute Treatment: 0.8 to 1.2 mEq/L
  • Maintenance Therapy: 0.6 to 1.0 mEq/L

Recommended Frequency of Monitoring:

  1. Initial Phase (Starting Treatment): Blood levels should be checked every few days after starting lithium or adjusting the dose until stable therapeutic levels are reached.
  2. Stabilization Phase :Once a stable dose is achieved, blood levels should be monitored every 1 to 2 weeks for the first few months.
  3. Maintenance Phase: After stabilization, monitoring can typically be reduced to every 2 to 3 months.
  4. Additional Situations Requiring Monitoring: If there are changes in dosage.

  5. If there are signs of toxicity or side effects.
    During periods of illness, dehydration, or significant changes in diet or medication that could affect lithium levels.

Regular monitoring is crucial because lithium has a narrow therapeutic window and can cause toxicity if levels become too high or lose effectiveness if too low. Always follow your healthcare provider's specific recommendations for your situation.

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